ParkinsonCanadaV1, Main, Exploration, bibRecord, 001678

Effect of Ser-129 Phosphorylation on Interaction of α-Synuclein with Synaptic and Cellular Membranes*

Identifieur interne : 001678 ( Main/Exploration ); précédent : 001677; suivant : 001679

Effect of Ser-129 Phosphorylation on Interaction of α-Synuclein with Synaptic and Cellular Membranes*

Auteurs : Naomi P. Visanji ; Sabine Wislet-Gendebien [Belgique] ; Loren W. Oschipok ; Gang Zhang ; Isabelle Aubert ; Paul E. Fraser ; Anurag Tandon [Canada]

Source :

The Journal of Biological Chemistry [ 0021-9258 ] ; 2011.

RBID : PMC:3195582

English descriptors

KwdEn :
- Amino Acid Substitution, Animals, Cell Line, Epitopes (genetics), Epitopes (metabolism), Humans, Lewy Bodies (genetics), Lewy Bodies (metabolism), Mice, Mice, Knockout, Mutation, Missense, Parkinsonian Disorders (genetics), Parkinsonian Disorders (metabolism), Protein Binding (genetics), Protein Kinases (biosynthesis), Protein Kinases (genetics), Protein Transport (genetics), Protein-Serine-Threonine Kinases (biosynthesis), Protein-Serine-Threonine Kinases (genetics), Synaptic Membranes (genetics), Synaptic Membranes (metabolism), alpha-Synuclein (genetics), alpha-Synuclein (metabolism).
MESH :
- chemical , biosynthesis : Protein Kinases, Protein-Serine-Threonine Kinases.
- chemical , genetics : Epitopes, Protein Kinases, Protein-Serine-Threonine Kinases, alpha-Synuclein.
- chemical , metabolism : Epitopes, alpha-Synuclein.
- genetics : Lewy Bodies, Parkinsonian Disorders, Protein Binding, Protein Transport, Synaptic Membranes.
- metabolism : Lewy Bodies, Parkinsonian Disorders, Synaptic Membranes.
- Amino Acid Substitution, Animals, Cell Line, Humans, Mice, Mice, Knockout, Mutation, Missense.

Abstract

Background: The majority of α-synuclein is phosphorylated at serine 129 in Lewy bodies.

Results: The membrane association of PD-linked mutant α-synuclein, but not wild-type α-synuclein, was increased by serine 129 phosphorylation.

Conclusion: Pathological serine 129 phosphorylation regulates membrane accumulation of mutant α-synuclein.

Significance: The relationship of serine 129 phosphorylation to pathogenic aggregation of normal and mutant α-synuclein may be governed by distinct effects on phosphoprotein membrane accumulation.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3195582

DOI: 10.1074/jbc.M111.253450
PubMed: 21849493
PubMed Central: 3195582

Affiliations:

Le document en format XML

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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Effect of Ser-129 Phosphorylation on Interaction of α-Synuclein with Synaptic and Cellular Membranes<xref ref-type="fn" rid="FN1">*</xref>
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<series><title level="j">The Journal of Biological Chemistry</title>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Amino Acid Substitution</term>
<term>Animals</term>
<term>Cell Line</term>
<term>Epitopes (genetics)</term>
<term>Epitopes (metabolism)</term>
<term>Humans</term>
<term>Lewy Bodies (genetics)</term>
<term>Lewy Bodies (metabolism)</term>
<term>Mice</term>
<term>Mice, Knockout</term>
<term>Mutation, Missense</term>
<term>Parkinsonian Disorders (genetics)</term>
<term>Parkinsonian Disorders (metabolism)</term>
<term>Protein Binding (genetics)</term>
<term>Protein Kinases (biosynthesis)</term>
<term>Protein Kinases (genetics)</term>
<term>Protein Transport (genetics)</term>
<term>Protein-Serine-Threonine Kinases (biosynthesis)</term>
<term>Protein-Serine-Threonine Kinases (genetics)</term>
<term>Synaptic Membranes (genetics)</term>
<term>Synaptic Membranes (metabolism)</term>
<term>alpha-Synuclein (genetics)</term>
<term>alpha-Synuclein (metabolism)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="biosynthesis" xml:lang="en"><term>Protein Kinases</term>
<term>Protein-Serine-Threonine Kinases</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Epitopes</term>
<term>Protein Kinases</term>
<term>Protein-Serine-Threonine Kinases</term>
<term>alpha-Synuclein</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Epitopes</term>
<term>alpha-Synuclein</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Lewy Bodies</term>
<term>Parkinsonian Disorders</term>
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<front><div type="abstract" xml:lang="en"><p><bold>Background:</bold>
 The majority of α-synuclein is phosphorylated at serine 129 in Lewy bodies.</p>
<p><bold>Results:</bold>
 The membrane association of PD-linked mutant α-synuclein, but not wild-type α-synuclein, was increased by serine 129 phosphorylation.</p>
<p><bold>Conclusion:</bold>
 Pathological serine 129 phosphorylation regulates membrane accumulation of mutant α-synuclein.</p>
<p><bold>Significance:</bold>
 The relationship of serine 129 phosphorylation to pathogenic aggregation of normal and mutant α-synuclein may be governed by distinct effects on phosphoprotein membrane accumulation.</p>
</div>
</front>
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<name sortKey="Visanji, Naomi P" sort="Visanji, Naomi P" uniqKey="Visanji N" first="Naomi P." last="Visanji">Naomi P. Visanji</name>
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<country name="Belgique"><region name="Province de Liège"><name sortKey="Wislet Gendebien, Sabine" sort="Wislet Gendebien, Sabine" uniqKey="Wislet Gendebien S" first="Sabine" last="Wislet-Gendebien">Sabine Wislet-Gendebien</name>
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<country name="Canada"><region name="Ontario"><name sortKey="Tandon, Anurag" sort="Tandon, Anurag" uniqKey="Tandon A" first="Anurag" last="Tandon">Anurag Tandon</name>
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La maladie de Parkinson au Canada (serveur d'exploration)

Effect of Ser-129 Phosphorylation on Interaction of α-Synuclein with Synaptic and Cellular Membranes*

Effect of Ser-129 Phosphorylation on Interaction of α-Synuclein with Synaptic and Cellular Membranes*

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

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	La maladie de Parkinson au Canada (serveur d'exploration)
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